One year after inclusion, the patients were reassessed.
Biopsy specimens scheduled for ultrastructural examination were fixed with glutaraldehyde and examined by electron microscopy.
Ambulatory 24 h ECGs were recorded with Medilog AR4 digital Holter monitors (Schiller AG, Baar, Switzerland) and edited in Medilog Excel V.3 by experienced nurses.
Objective Dilated cardiomyopathy (DCM) is characterised by left ventricular dilation and dysfunction not caused by coronary disease, valvular disease or hypertension.
Owing to the considerable aetiological and prognostic heterogeneity in DCM, an extensive diagnostic work-up is recommended.
In a seminal paper by Felker ,3 an endomyocardial biopsy identified the underlying cause in 15% of patients referred to the Johns Hopkins Hospital for diagnostic evaluation of dilated cardiomyopathy.